Variability in Declining Haloperidol and Reduced Haloperidol Plasma Concentrations upon Haloperidol Cessation

Shih Ku Lin, Wen Ho Chang, Y. W.Francis Lam, Michael W. Jann

Research output: Contribution to journalArticle

Abstract

Plasma concentrations of haloperidol and its reduced metabolite were measured in 6 schizophrenic patients after discontinuation of oral haloperidol treatment. Patients were on haloperidol 10mg twice daily for at least 2 to 4 weeks prior to cessation of treatment to ensure haloperidol steady-state concentrations had been achieved. Blood samples were obtained at 12, 24, 36, 60 and 84 hours following drug discontinuation. Haloperidol and reduced haloperidol were assayed by high-performance liquid chromatography with a lower limit of sensitivity of 0.2 μg/L and inter- and intra-assay coefficients of variation of less than 4 to 12% at 2 to 10 μg/L. Declining plasma concentrations of both haloperidol and reduced haloperidol were observed in each patient. Three of 5 patients had increased oscillations of either plasma haloperidol or reduced haloperidol concentrations at different times during the 84-hour period following withdrawal of haloperidol therapy. It is suggested that enterohepatic recycling could account for these oscillations.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalDrug Investigation
Volume5
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Variability in Declining Haloperidol and Reduced Haloperidol Plasma Concentrations upon Haloperidol Cessation'. Together they form a unique fingerprint.

  • Cite this