Validation of a latent variable representing the dementing process

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The cognitive correlates of functional status are essential to dementia case-finding. Nevertheless, cognitive performance is a generally weak predictor of functional outcomes. We have employed structural equation models to explicitly distinguish functional status, and therefore "dementia- relevant" variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together, g' + δ encompass Spearman's g. Although δ represents only a small fraction of the total variance in cognitive task performance, it is more strongly associated with dementia status than is g'. In this study, we validate δ in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. Our approach results in "error free" continuous variables. This suggests that δ can serve as a dementia specific endophenotype. As a result, future studies may be able to associate δ with inflammatory and genetic biomarkers.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalJournal of Alzheimer's Disease
Volume30
Issue number3
DOIs
StatePublished - 2012

Keywords

  • Aging
  • cognition
  • dementia
  • functional status
  • g

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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