Validation of a latent construct for dementia case-finding in Mexican-Americans

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have constructed a latent dementia proxy, 'δ', and validated it in several datasets, including well characterized subjects participating in the Texas Alzheimer's Research and Care Consortium (TARCC) study. It may be possible to construct δ homologs from almost any ad hoc combination of cognitive and functional status measures. δ homologs may also be relatively immune to measurement error, including cultural, linguistic, or educational biases. These properties make factor scores derived from latent variables a potentially attractive solution for dementia case-finding in rural or minority populations. Here we have explored an alternative and briefer assessment by which to construct a δ homolog and validate the resulting latent variable (dMA) in Mexican-American (MA) TARCC subjects. dMA, composed of simple 'bedside' dementia screening instruments, achieves Areas Under the Receiver Operative Curve that rival those of δ itself. Ethnicity has a small effect on dMA's performance. These results suggest that it may be possible to validly export dMA into other MA populations, or to export δ homolog factor scores from one population to another.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalJournal of Alzheimer's Disease
Volume37
Issue number1
DOIs
StatePublished - 2013

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Dementia
Population
Proxy
Linguistics
Research
Datasets

Keywords

  • Aging
  • cognition
  • dementia
  • functional status
  • g

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Validation of a latent construct for dementia case-finding in Mexican-Americans. / Royall, Donald R; Palmer, Ray.

In: Journal of Alzheimer's Disease, Vol. 37, No. 1, 2013, p. 89-97.

Research output: Contribution to journalArticle

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