Vaginal fluid human chorionic gonadotropin for detection of rupture of membranes

Ronald Beesley, Naomi Trevino, Michael Smyth, Claire Gould, Randal Robinson

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To evaluate the accuracy of Qualitative and quantitative human chorionic gonadotropin (hCG) assays to detect ruptured amniotic membranes (ROM) in term patients. STUDY DESIGN: We conducted a prospective cohort study enrolling 100 term pregnancies with intact membranes. Samples were collected before and immediately following ROM, and at 2 and 4 hours post-ROM. Quantitative and qualitative hCG assays were performed on all samples. Outcome measures included the detection and measured amount of hCG before and after ROM. Sensitivity, specificity and positive predictive values for the qualitative assays were determined. RESULTS: A total of 98% pre-ROM and 100% post-ROM qualitative assays tested positive with mean quantitative hCG levels of 181.30 mIU/mL and 208.24 mIU/mL, respectively. The qualitative post-ROM sensitivity was 100%; however, the pre-ROM specificity was only 2%. The positive predictive value for detecting ROM was 50%. CONCLUSION: Qualitative and quantitative hCG assays are not useful for determining ROM in term preg-nancies.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume53
Issue number11
StatePublished - Nov 1 2008
Externally publishedYes

Keywords

  • Human chorionic gonadotropin
  • Rupture of membranes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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