Vaccinia Virus (Poxviridae)

Yan Xiang; Rebecca K. Lane

doi:10.1016/B978-0-12-814515-9.00047-3

Vaccinia Virus (Poxviridae)

Yan Xiang, Rebecca K. Lane

Department of Microbiology, Immunology & Molecular Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Vaccinia virus (VACV) is the most comprehensively studied member of the family Poxviridae, serving as the prototype for this large group of complex dsDNA viruses that include many human or veterinary pathogens. Genetically and antigenically closely related to variola virus, the causative agent of smallpox, VACV has been an effective smallpox vaccine and is largely responsible for the eradication of the disease. Today, VACV is employed as a versatile vector for developing vaccines against other infectious diseases and cancer, and studies of VACV continue to provide novel understanding of viral replication, viral pathogenesis, and host immunity.

Original language	English (US)
Title of host publication	Encyclopedia of Virology
Subtitle of host publication	Volume 1-5, Fourth Edition
Publisher	Elsevier
Pages	854-859
Number of pages	6
Volume	1-5
ISBN (Electronic)	9780128145166
DOIs	https://doi.org/10.1016/B978-0-12-814515-9.00047-3
State	Published - Jan 1 2020

Keywords

Attenuation
Entry
Expression vectors
Genome
Host range gene
Immune evasion
Immune response
Jenner
Morphogenesis
Poxvirus
Replication
Smallpox vaccine
Transcription
Virions
Virulence

ASJC Scopus subject areas

General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-814515-9.00047-3

Cite this

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title = "Vaccinia Virus (Poxviridae)",

abstract = "Vaccinia virus (VACV) is the most comprehensively studied member of the family Poxviridae, serving as the prototype for this large group of complex dsDNA viruses that include many human or veterinary pathogens. Genetically and antigenically closely related to variola virus, the causative agent of smallpox, VACV has been an effective smallpox vaccine and is largely responsible for the eradication of the disease. Today, VACV is employed as a versatile vector for developing vaccines against other infectious diseases and cancer, and studies of VACV continue to provide novel understanding of viral replication, viral pathogenesis, and host immunity.",

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AU - Lane, Rebecca K.

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N2 - Vaccinia virus (VACV) is the most comprehensively studied member of the family Poxviridae, serving as the prototype for this large group of complex dsDNA viruses that include many human or veterinary pathogens. Genetically and antigenically closely related to variola virus, the causative agent of smallpox, VACV has been an effective smallpox vaccine and is largely responsible for the eradication of the disease. Today, VACV is employed as a versatile vector for developing vaccines against other infectious diseases and cancer, and studies of VACV continue to provide novel understanding of viral replication, viral pathogenesis, and host immunity.

AB - Vaccinia virus (VACV) is the most comprehensively studied member of the family Poxviridae, serving as the prototype for this large group of complex dsDNA viruses that include many human or veterinary pathogens. Genetically and antigenically closely related to variola virus, the causative agent of smallpox, VACV has been an effective smallpox vaccine and is largely responsible for the eradication of the disease. Today, VACV is employed as a versatile vector for developing vaccines against other infectious diseases and cancer, and studies of VACV continue to provide novel understanding of viral replication, viral pathogenesis, and host immunity.

KW - Attenuation

KW - Entry

KW - Expression vectors

KW - Genome

KW - Host range gene

KW - Immune evasion

KW - Immune response

KW - Jenner

KW - Morphogenesis

KW - Poxvirus

KW - Replication

KW - Smallpox vaccine

KW - Transcription

KW - Virions

KW - Virulence

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AN - SCOPUS:85148848540

VL - 1-5

SP - 854

EP - 859

BT - Encyclopedia of Virology

PB - Elsevier

ER -

Vaccinia Virus (Poxviridae)

Abstract

Keywords

ASJC Scopus subject areas

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