Vaccinia Virus (Poxviridae)

Yan Xiang, Rebecca K. Lane

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Vaccinia virus (VACV) is the most comprehensively studied member of the family Poxviridae, serving as the prototype for this large group of complex dsDNA viruses that include many human or veterinary pathogens. Genetically and antigenically closely related to variola virus, the causative agent of smallpox, VACV has been an effective smallpox vaccine and is largely responsible for the eradication of the disease. Today, VACV is employed as a versatile vector for developing vaccines against other infectious diseases and cancer, and studies of VACV continue to provide novel understanding of viral replication, viral pathogenesis, and host immunity.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Virology
Subtitle of host publicationVolume 1-5, Fourth Edition
PublisherElsevier
Pages854-859
Number of pages6
Volume1-5
ISBN (Electronic)9780128145166
DOIs
StatePublished - Jan 1 2020

Keywords

  • Attenuation
  • Entry
  • Expression vectors
  • Genome
  • Host range gene
  • Immune evasion
  • Immune response
  • Jenner
  • Morphogenesis
  • Poxvirus
  • Replication
  • Smallpox vaccine
  • Transcription
  • Virions
  • Virulence

ASJC Scopus subject areas

  • General Immunology and Microbiology

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