Vaccines against viral hemorrhagic fevers: Non-human primate models

Ricardo Carrion, Jean L. Patterson

    Research output: Contribution to journalReview article

    4 Scopus citations

    Abstract

    Viral hemorrhagic fevers are a group of disease syndromes caused by infection with certain RNA viruses. The disease is marked by a febrile response, malaise, coagulopathy and vascular permeability culminating in death. Case fatality rates can reach 90% depending on the etiologic agent. Currently, there is no approved antiviral treatment. Because of the high case fatality, risk of importation and the potential to use these agents as biological weapons, development of countermeasures to these agents is a high priority. The sporadic nature of disease outbreaks and the ethical issues associated with conducting a human trial for such diseases make human studies impractical; therefore, development of countermeasures must occur in relevant animal models. Non-human primates are superior models to study infectious disease because their immune system is similar to humans and they are good predictors of efficacy in vaccine development and other intervention strategies. This review article summarizes viral hemorrhagic fever non-human primate models.

    Original languageEnglish (US)
    Pages (from-to)667-673
    Number of pages7
    JournalHuman Vaccines
    Volume7
    Issue number6
    DOIs
    StatePublished - Jun 1 2011

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    Keywords

    • Ebola
    • Junin
    • Lassa
    • Macaque
    • Marburg
    • Marmoset
    • Monkey
    • Rift valley fever

    ASJC Scopus subject areas

    • Immunology
    • Pharmacology, Toxicology and Pharmaceutics(all)

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