Vaccines against viral hemorrhagic fevers

Non-human primate models

Ricardo Carrion, Jean L. Patterson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Viral hemorrhagic fevers are a group of disease syndromes caused by infection with certain RNA viruses. The disease is marked by a febrile response, malaise, coagulopathy and vascular permeability culminating in death. Case fatality rates can reach 90% depending on the etiologic agent. Currently, there is no approved antiviral treatment. Because of the high case fatality, risk of importation and the potential to use these agents as biological weapons, development of countermeasures to these agents is a high priority. The sporadic nature of disease outbreaks and the ethical issues associated with conducting a human trial for such diseases make human studies impractical; therefore, development of countermeasures must occur in relevant animal models. Non-human primates are superior models to study infectious disease because their immune system is similar to humans and they are good predictors of efficacy in vaccine development and other intervention strategies. This review article summarizes viral hemorrhagic fever non-human primate models.

Original languageEnglish (US)
Pages (from-to)667-673
Number of pages7
JournalHuman Vaccines
Volume7
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Viral Hemorrhagic Fevers
Primates
Vaccines
Biological Warfare Agents
RNA Viruses
Capillary Permeability
Ethics
Antiviral Agents
Disease Outbreaks
Communicable Diseases
Immune System
Fever
Animal Models
Mortality
Infection
Therapeutics

Keywords

  • Ebola
  • Junin
  • Lassa
  • Macaque
  • Marburg
  • Marmoset
  • Monkey
  • Rift valley fever

ASJC Scopus subject areas

  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Vaccines against viral hemorrhagic fevers : Non-human primate models. / Carrion, Ricardo; Patterson, Jean L.

In: Human Vaccines, Vol. 7, No. 6, 06.2011, p. 667-673.

Research output: Contribution to journalArticle

Carrion, Ricardo ; Patterson, Jean L. / Vaccines against viral hemorrhagic fevers : Non-human primate models. In: Human Vaccines. 2011 ; Vol. 7, No. 6. pp. 667-673.
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