Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data

Andreas Beyerlein, Andreas N. Strobl, Christiane Winkler, Michaela Carpus, Annette Knopff, Ewan Donnachie, Donna P. Ankerst, Anette G. Ziegler

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aims/hypothesis Vaccinations in early childhood potentially stimulate the immune system and may thus be relevant for the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). We determined the association of vaccination burden with T1D-associated islet autoimmunity in children with high familial risk followed prospectively from birth. Methods A total of 20,570 certified vaccination records from 1918 children were correlated with time to onset of T1D-associated islet autoimmunity using Cox regression, considering multiple time periods up until age two years and vaccination types, and adjusting for HLA genotype, sex, delivery mode, season of birth, preterm delivery and maternal T1D status. Additionally, prospective claims data of 295,420 subjects were used to validate associations for the tick-borne encephalitis (TBE) vaccination. Results Most vaccinations were not associated with a significantly increased hazard ratio (HR) for islet autoimmunity (e.g. HR [95% confidence interval]: 1.08 [0.96–1.21] per additional vaccination against measles, mumps and rubella at age 0–24 months). TBE vaccinations within the first two years of life were nominally associated with a significantly increased autoimmunity risk (HR: 1.44 [1.06–1.96] per additional vaccination at age 0–24 months), but this could not be confirmed with respect to outcome T1D in the validation cohort (HR: 1.02 [0.90–1.16]). Conclusions We found no evidence that early vaccinations increase the risk of T1D-associated islet autoimmunity development. The potential association with early TBE vaccinations could not be confirmed in an independent cohort and appears to be a false positive finding.

Original languageEnglish (US)
Pages (from-to)1735-1741
Number of pages7
JournalVaccine
Volume35
Issue number14
DOIs
StatePublished - Mar 27 2017

Keywords

  • Islet autoimmunity
  • Type 1 diabetes
  • Vaccinations

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Beyerlein, A., Strobl, A. N., Winkler, C., Carpus, M., Knopff, A., Donnachie, E., Ankerst, D. P., & Ziegler, A. G. (2017). Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data. Vaccine, 35(14), 1735-1741. https://doi.org/10.1016/j.vaccine.2017.02.049