Vaccination with the defined chlamydial secreted protein CPAF induces robust protection against female infertility following repeated genital chlamydial challenge

Ashlesh K. Murthy, Weidang Li, M. Neal Guentzel, Guangming Zhong, Bernard P. Arulanandam

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We previously have shown the efficacy of recombinant (r) chlamydial protease-like activity factor (CPAF) vaccination against hydrosalpinx development following primary genital chlamydial challenge. In this study, we evaluated further the protection induced by rCPAF vaccination against infertility. Following primary challenge, fertility levels were not significantly different between the mock- and CPAF-vaccinated and Chlamydia alone challenged mice. However, following secondary genital chlamydial challenge, mock (PBS) immunized mice displayed a significant reduction of fertility compared to age-matched naïve mice, while mice vaccinated intranasally with rCPAF + CpG displayed significant prevention of infertility. These results suggest that hydrosalpinx may be a reliable indicator of impending infertility, and that rCPAF is a promising candidate to prevent infertility resulting from repeated genital chlamydial infections.

Original languageEnglish (US)
Pages (from-to)2519-2522
Number of pages4
JournalVaccine
Volume29
Issue number14
DOIs
StatePublished - Mar 21 2011

Keywords

  • Chlamydia
  • Chlamydial protease-like activity factor
  • Fertility
  • Genital infection
  • Infertility
  • Intranasal
  • Repeated infections
  • Secondary challenge
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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