Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing

Zhiqiang Ma, Liqun Xu, Dong Liu, Xiaoyan Zhang, Shouyin Di, Weimiao Li, Jiao Zhang, Russel J. Reiter, Jing Han, Xiaofei Li, Xiaolong Yan

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Persistent senescence seems to exert detrimental effects fostering ageing and age-related disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer, but its clinical application is limited due to adverse side effects. Melatonin is a potent antioxidant and antiageing molecule, is nontoxic, and enhances the efficacy and reduces the side effects of chemotherapy. In this review, we first summarize the mitochondrial protective role of melatonin in the context of chemotherapeutic drug-induced toxicity. Thereafter, we tabulate the protective actions of melatonin against ageing and the harmful roles induced by chemotherapy and chemotherapeutic agents, including anthracyclines, alkylating agents, platinum, antimetabolites, mitotic inhibitors, and molecular-targeted agents. Finally, we discuss several novel directions for future research in this area. The information compiled in this review will provide a comprehensive reference for the protective activities of melatonin in the context of chemotherapy drug-induced toxicity and will contribute to the design of future studies and increase the potential of melatonin as a therapeutic agent.

Original languageEnglish (US)
Article number6841581
JournalOxidative Medicine and Cellular Longevity
Volume2020
DOIs
StatePublished - 2020

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Fingerprint Dive into the research topics of 'Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing'. Together they form a unique fingerprint.

  • Cite this