Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists : Endorsed by the Mycoses Study Group Education and Research Consortium

Erin K. McCreary, Matthew R. Davis, Navaneeth Narayanan, David R. Andes, Dario Cattaneo, Robbie Christian, Russell E. Lewis, Kevin M. Watt, Nathan P. Wiederhold, Melissa D. Johnson

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, known drug interactions, and established relationships between exposure and response. On behalf of the Society of Infectious Diseases Pharmacists (SIDP), this insight describes the pharmacokinetic principles and pharmacodynamic targets of commonly used triazole antifungals and provides the rationale for utility of TDM within each agent.

Original languageEnglish (US)
Pages (from-to)1043-1050
Number of pages8
JournalPharmacotherapy
Volume43
Issue number10
DOIs
StatePublished - Oct 2023

Keywords

  • fluconazole
  • isavuconazole
  • itraconazole
  • pharmacodynamics
  • pharmacokinetics
  • posaconazole
  • voriconazole

ASJC Scopus subject areas

  • Pharmacology (medical)

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