Utilisation of bivalirudin and vascular closure devices for same-day discharge after percutaneous coronary and peripheral interventions

Radosław J. Szymański, Radosław S. Kiesz, Szymon Wiernek, Barbara Wiernek, Damian Kawecki, Marcin Dȩbiński, Marek Kondys, Radosław Olszewski, Jacek Szyguła, Paweł E. Buszman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Currently the majority of coronary and peripheral interventions are performed with an overnight stay. This increases the cost and does not reduce logistic constraints on hospital resources. We hypothesised that by combining bivalirudin with vascular closure devices we can safely discharge patients on the same day after percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) without increasing their risk of bleeding. Aim: To evaluate the safety and the feasibility of same-day discharge after PCI and PTA using bivalirudin and vascular closure devices. Methods: This is a retrospective analysis of 833 consecutive patients who underwent percutaneous procedures in our centre between January 2007 and February 2010. The population was divided into interventional and diagnostic arms. All interventions were done with use of bivalirudin for anticoagulation and vascular closure devices for achieving haemostasis. Haemostasis in the diagnostic cohort was achieved with standard manual compression. The mean time of observation was 30 days. The mean age of patients was 64.3 years. The primary endpoint was any bleeding event meeting GUSTO criteria. The secondary endpoints included local vascular complications, major adverse cardiac and cerebrovascular events, time to ambulation and discharge, as well as need for overnight hospitalisation. Results: In 30-day observation the primary endpoint occurred in 4.0% of patients in the interventional group and in 2.6% of patients in the diagnostic group (p = 0.31). The frequency of local vascular complications was higher in the interventional group although it was not statistically significant (3.1% vs. 2.9%; p = 0.33). Patients from the interventional group were ambulated sooner compared to the diagnostic group (117.5 vs. 131 min; p = 0.003). Time to discharge was 316.4 ± 38.7 min and 214.2 ± 23.4 min for interventional and diagnostic procedures, respectively (p < 0.001). Conclusions: PCI and PTA in the selected group of patients, with use of bivalirudin and vascular closure devices, do not appear to have increased risk of post-procedural events when compared to diagnostic procedures, and can be done safely without the need for an overnight stay.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalKardiologia Polska
Issue number6
StatePublished - Jun 15 2016
Externally publishedYes


  • Bivalirudin
  • Same day discharge
  • Vascular closure devices

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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