Uterine sensitivity to prostaglandins in the pregnant rabbit: A method for testing the effect of previous administration of small doses of PGF2α for short periods

G. W. Smith; Margaret Abel; P. W. Nathanielsz

doi:10.1016/0090-6980(73)90162-7

Uterine sensitivity to prostaglandins in the pregnant rabbit: A method for testing the effect of previous administration of small doses of PGF_2α for short periods

G. W. Smith, Margaret Abel, P. W. Nathanielsz

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Using an intrauterine pressure transducer to telemeter uterine pressure a method has been devised to assess the sensitivity of the uterus to intra-aortic PGF_2α infusions. Intra-aortic infusion of 1-10 μg PGF_2α/min into the 21-24 Day Pregnant rabbit has little effect on uterine contractility. A continuous intra-aortic infusion of 1 μg PGF_2α/h was found to result in a gradual increase of sensitivity to PGF_2α even after cessation of the continuous infusion.

Original language	English (US)
Pages (from-to)	525-530
Number of pages	6
Journal	Prostaglandins
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0090-6980(73)90162-7
State	Published - Apr 1973
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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abstract = "Using an intrauterine pressure transducer to telemeter uterine pressure a method has been devised to assess the sensitivity of the uterus to intra-aortic PGF2α infusions. Intra-aortic infusion of 1-10 μg PGF2α/min into the 21-24 Day Pregnant rabbit has little effect on uterine contractility. A continuous intra-aortic infusion of 1 μg PGF2α/h was found to result in a gradual increase of sensitivity to PGF2α even after cessation of the continuous infusion.",

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AU - Abel, Margaret

AU - Nathanielsz, P. W.

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AB - Using an intrauterine pressure transducer to telemeter uterine pressure a method has been devised to assess the sensitivity of the uterus to intra-aortic PGF2α infusions. Intra-aortic infusion of 1-10 μg PGF2α/min into the 21-24 Day Pregnant rabbit has little effect on uterine contractility. A continuous intra-aortic infusion of 1 μg PGF2α/h was found to result in a gradual increase of sensitivity to PGF2α even after cessation of the continuous infusion.

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