Uterine sensitivity to prostaglandins in the pregnant rabbit: A method for testing the effect of previous administration of small doses of PGF for short periods

G. W. Smith, Margaret Abel, P. W. Nathanielsz

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Using an intrauterine pressure transducer to telemeter uterine pressure a method has been devised to assess the sensitivity of the uterus to intra-aortic PGF infusions. Intra-aortic infusion of 1-10 μg PGF/min into the 21-24 Day Pregnant rabbit has little effect on uterine contractility. A continuous intra-aortic infusion of 1 μg PGF/h was found to result in a gradual increase of sensitivity to PGF even after cessation of the continuous infusion.

Original languageEnglish (US)
Pages (from-to)525-530
Number of pages6
JournalProstaglandins
Volume3
Issue number4
DOIs
StatePublished - Apr 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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