Using Operant Reach Chambers to Assess Mouse Skilled Forelimb Use After Stroke

Dene Betz, April M. Becker, Katherine M. Cotter, Andrew M. Sloan, Ann M. Stowe, Mark P. Goldberg

Research output: Contribution to journalArticlepeer-review


Skilled forelimb reaching and grasping are important components of rodent motor performance. The isometric pull task can serve as a tool for quantifying forelimb function following stroke or other CNS injury as well as in forelimb rehabilitation. This task has been extensively developed for use in rats. Here, we describe methods of setup and training of an operant reach chamber for mice. Using a reward of peanut oil, mice are adaptively trained to pull a handle positioned slightly outside of an operant chamber, with automated recording of the number of attempts, force generated, success rate, and latency to maximal force.

Original languageEnglish (US)
Pages (from-to)327-343
Number of pages17
JournalMethods in molecular biology (Clifton, N.J.)
StatePublished - 2023


  • Forelimb function
  • Isometric pull task
  • Motor Impairment
  • Operant reach chambers
  • Stroke

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology


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