Using microRNA-122 mimics or microRNA-451 inhibitors to prevent the osteoarthritis process

Kayla M. Scott, Madeline Hays, David J. Cohen, Zvi Schwartz, Barbara D. Boyan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: MicroRNAs (miR) are short, non-coding segments of RNA that play a vital role in post-transcriptional gene regulation by binding to mRNA and preventing translation. Several studies have demonstrated that miRNA are regulated during the progression of osteoarthritis (OA) via agonistic or antagonistic mechanisms. OA is characterized by an increased production of inflammatory cytokines and matrix degrading enzymes such as matrix metalloproteinase 13 (MMP-13). These catabolic cytokines, most notably interleukin-1 beta (IL-1β), signal in an autocrine and paracrine manner, stimulating their own production and the production of catabolic pathway mediators. Interrupting these pathways through miR regulation could provide a novel approach that targets the underlying biological mechanism driving the disease progression. miR-122 and mi-451 are produced by rat articular chondrocytes (rArCs); miR-122 stimulates proliferation whereas miR-451 inhibits proliferation and stimulates production of the catabolic enzyme, matrix metalloproteinase 13 (MMP-13). The aim of this study was to determine if adding miR-122 or inhibiting miR-451 would have a protective effect on the production of inflammatory mediators and how endogenous levels of these two microRNA change in OA in vivo.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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