Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

Omar E. Christian, Jennifer Compton, Keisha R. Christian, Susan L. Mooberry, Fredrick A. Valeriote, Phillip Crews

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

Original languageEnglish (US)
Pages (from-to)1592-1597
Number of pages6
JournalJournal of Natural Products
Volume68
Issue number11
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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