Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi

Omar E. Christian, Jennifer Compton, Keisha R. Christian, Susan L Mooberry, Fredrick A. Valeriote, Phillip Crews

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.

Original languageEnglish (US)
Pages (from-to)1592-1597
Number of pages6
JournalJournal of Natural Products
Volume68
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

jasplakinolide
Diaporthe
leukemia
secondary metabolites
colon
actin
cell lines
fungi
mice
Metabolites
Fungi
Colonic Neoplasms
Actins
Leukemia
Cells
Cell Line
neoplasm cells
chaetoglobosins

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi. / Christian, Omar E.; Compton, Jennifer; Christian, Keisha R.; Mooberry, Susan L; Valeriote, Fredrick A.; Crews, Phillip.

In: Journal of Natural Products, Vol. 68, No. 11, 11.2005, p. 1592-1597.

Research output: Contribution to journalArticle

Christian, Omar E. ; Compton, Jennifer ; Christian, Keisha R. ; Mooberry, Susan L ; Valeriote, Fredrick A. ; Crews, Phillip. / Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi. In: Journal of Natural Products. 2005 ; Vol. 68, No. 11. pp. 1592-1597.
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