Using gene sets to identify putative drugs for breast cancer

Tzu Hung Hsiao, Hung I.Harry Chen, Yidong Chen, Yu Heng Chen, Eric Y. Chuang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The number of current anti-cancer drugs was limited and the response rates were also not high. To "?reposition" known drugs as anti-cancer drugs to increase the therapeutic efficiency, we presented a novel analysis framework to identify putative drugs for cancer. Using breast cancer as example, a "cancer - gene sets - drugs" network was constructed through two procedures. First, the "gene sets - drugs" network was built by applying the expression pattern of drugs for gene set enrichment analysis. Secondly, the breast cancer progression associated gene sets were identified by survival analysis of patient cohorts. By integrating the two results, 25 tumor progression associated gene sets and 360 putative anti-cancer drugs were identified. Our method has the ability to identify the "reposition" drugs and the potential affected mechanisms of tumor progression concurrently. It will be useful to speed up the development of anti-cancer drugs from bench to clinical application.

Original languageEnglish (US)
Title of host publicationProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012
Pages552-555
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM2012 - Philadelphia, PA, United States
Duration: Oct 4 2012Oct 7 2012

Publication series

NameProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012

Other

Other2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM2012
CountryUnited States
CityPhiladelphia, PA
Period10/4/1210/7/12

Keywords

  • breast cancer
  • drug
  • gene set

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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  • Cite this

    Hsiao, T. H., Chen, H. I. H., Chen, Y., Chen, Y. H., & Chuang, E. Y. (2012). Using gene sets to identify putative drugs for breast cancer. In Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012 (pp. 552-555). [6392616] (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012). https://doi.org/10.1109/BIBM.2012.6392616