Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

Chaofeng Dai; Lisa H. Cazares; Lifang Wang; Yong Chu; Siming L. Wang; Dean A. Troyer; O. John Semmes; Richard R. Drake; Binghe Wang

doi:10.1039/c1cc11814e

Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

Chaofeng Dai, Lisa H. Cazares, Lifang Wang, Yong Chu, Siming L. Wang, Dean A. Troyer, O. John Semmes, Richard R. Drake, Binghe Wang

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

Original language	English (US)
Pages (from-to)	10338-10340
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	37
DOIs	https://doi.org/10.1039/c1cc11814e
State	Published - Oct 7 2011
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc11814e

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title = "Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen",

abstract = "Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.",

author = "Chaofeng Dai and Cazares, {Lisa H.} and Lifang Wang and Yong Chu and Wang, {Siming L.} and Troyer, {Dean A.} and Semmes, {O. John} and Drake, {Richard R.} and Binghe Wang",

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T1 - Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

AU - Dai, Chaofeng

AU - Cazares, Lisa H.

AU - Wang, Lifang

AU - Chu, Yong

AU - Wang, Siming L.

AU - Troyer, Dean A.

AU - Semmes, O. John

AU - Drake, Richard R.

AU - Wang, Binghe

PY - 2011/10/7

Y1 - 2011/10/7

N2 - Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

AB - Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

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DO - 10.1039/c1cc11814e

M3 - Article

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AN - SCOPUS:80052533662

SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

Abstract

ASJC Scopus subject areas

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