Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Jennifer R. Cope; Dennis A. Conrad; Naiomi Cohen; Manuel Cotilla; Alexandre Dasilva; Jonathan Jackson; Govinda S. Visvesvara

doi:10.1093/cid/civ1021

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Jennifer R. Cope, Dennis A. Conrad, Naiomi Cohen, Manuel Cotilla, Alexandre Dasilva, Jonathan Jackson, Govinda S. Visvesvara

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

Original language	English (US)
Pages (from-to)	774-776
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	62
Issue number	6
DOIs	https://doi.org/10.1093/cid/civ1021
State	Published - Jul 10 2015
Externally published	Yes

Keywords

Miltefosine
Naegleria fowleri
Primary amebic meningoencephalitis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/civ1021

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title = "Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case",

abstract = "Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.",

keywords = "Miltefosine, Naegleria fowleri, Primary amebic meningoencephalitis",

author = "Cope, {Jennifer R.} and Conrad, {Dennis A.} and Naiomi Cohen and Manuel Cotilla and Alexandre Dasilva and Jonathan Jackson and Visvesvara, {Govinda S.}",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Oxford University Press for the Infectious Diseases Society of America 2015.",

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language = "English (US)",

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AU - Cope, Jennifer R.

AU - Conrad, Dennis A.

AU - Cohen, Naiomi

AU - Cotilla, Manuel

AU - Dasilva, Alexandre

AU - Jackson, Jonathan

AU - Visvesvara, Govinda S.

PY - 2015/7/10

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N2 - Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

AB - Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

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KW - Naegleria fowleri

KW - Primary amebic meningoencephalitis

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Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Abstract

Keywords

ASJC Scopus subject areas

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