Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Jennifer R. Cope; Dennis A. Conrad; Naiomi Cohen; Manuel Cotilla; Alexandre Dasilva; Jonathan Jackson; Govinda S. Visvesvara

doi:10.1093/cid/civ1021

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Jennifer R. Cope, Dennis A. Conrad, Naiomi Cohen, Manuel Cotilla, Alexandre Dasilva, Jonathan Jackson, Govinda S. Visvesvara

Pediatrics

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

Original language	English (US)
Pages (from-to)	774-776
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	62
Issue number	6
DOIs	https://doi.org/10.1093/cid/civ1021
State	Published - Jul 10 2015

Keywords

Miltefosine
Naegleria fowleri
Primary amebic meningoencephalitis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/civ1021

Fingerprint Dive into the research topics of 'Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case'. Together they form a unique fingerprint.

Cite this

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis : Report of 1 Fatal and 1 Surviving Case. / Cope, Jennifer R.; Conrad, Dennis A.; Cohen, Naiomi; Cotilla, Manuel; Dasilva, Alexandre; Jackson, Jonathan; Visvesvara, Govinda S.

In: Clinical Infectious Diseases, Vol. 62, No. 6, 10.07.2015, p. 774-776.

Research output: Contribution to journal › Article › peer-review

@article{408c9f8f8ee741a4965b8fbb5bf7b93e,

title = "Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case",

abstract = "Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.",

keywords = "Miltefosine, Naegleria fowleri, Primary amebic meningoencephalitis",

author = "Cope, {Jennifer R.} and Conrad, {Dennis A.} and Naiomi Cohen and Manuel Cotilla and Alexandre Dasilva and Jonathan Jackson and Visvesvara, {Govinda S.}",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Oxford University Press for the Infectious Diseases Society of America 2015. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2015",

month = jul,

day = "10",

doi = "10.1093/cid/civ1021",

language = "English (US)",

volume = "62",

pages = "774--776",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis

T2 - Report of 1 Fatal and 1 Surviving Case

AU - Cope, Jennifer R.

AU - Conrad, Dennis A.

AU - Cohen, Naiomi

AU - Cotilla, Manuel

AU - Dasilva, Alexandre

AU - Jackson, Jonathan

AU - Visvesvara, Govinda S.

PY - 2015/7/10

Y1 - 2015/7/10

N2 - Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

AB - Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

KW - Miltefosine

KW - Naegleria fowleri

KW - Primary amebic meningoencephalitis

UR - http://www.scopus.com/inward/record.url?scp=84960078706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960078706&partnerID=8YFLogxK

U2 - 10.1093/cid/civ1021

DO - 10.1093/cid/civ1021

M3 - Article

C2 - 26679626

AN - SCOPUS:84960078706

VL - 62

SP - 774

EP - 776

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 6

ER -

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this