Use of stereotactic body radiation therapy for medically inoperable multiple primary lung cancer

Chance Matthiesen, J. Spencer Thompson, Tania De La Fuente Herman, Salahuddin Ahmad, Terence Herman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Introduction: To review outcomes of medically inoperable patients treated with stereotactic body radiation therapy (SBRT) for multiple primary lung cancer (MPLC). Methods: We retrospectively reviewed the charts of 10 patients (21 lesions) treated with SBRT for synchronous (seven), metachronous (one) or synchronous/metachronous lung cancers. All patients were male, medically inoperable and had a median age of 66 years. Eight patients had bilateral disease and two had unilateral disease. All patients had a histological diagnosis in at least one of the two lesions and four patients (44.4%) had both lesions biopsied. There were 18 T1 lesions and three T2 lesions. SBRT was in three fractions of 20 Gy or five fractions of 11-12 Gy to each lesion. Results: Mean and median follow up were 18.8 and 15.5 months, respectively. At analysis, six patients (60.0%) are alive, and five of these living patients (83.3%) have no evidence of disease recurrence or progression. Four patients (44.4%) developed distant metastatic disease. Twenty lesions (95.2%) achieved in-field local control. No patients experienced acute pulmonary complications and only two patients (22.2%) experienced late grade I lung toxicity as per the Radiation Therapy Oncology Group toxicity criteria. Conclusion: SBRT for MPLC in medically inoperable patients is a safe, feasible and effective treatment approach.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalJournal of Medical Imaging and Radiation Oncology
Issue number5
StatePublished - Oct 2012
Externally publishedYes


  • lung cancer
  • multiple primary lung cancer
  • radiation therapy
  • SBRT
  • synchronous/metachronous lung cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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