Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm

Julio C Palmaz, Fermin O. Tio, Jean Claude Laborde, Michael Clem, Frank J. Rivera, Kenneth D. Murphy, Carlos E. Encarnacion

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Purpose: To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE). Materials and Methods: Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples. Results: Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12% and 17% from controls, respectively. Conclusion: Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.

Original languageEnglish (US)
Pages (from-to)879-885
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume6
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Abdominal Aortic Aneurysm
Polytetrafluoroethylene
Stents
Aortography
Neointima
Equipment and Supplies
Tensile Strength
Aortic Aneurysm
Fascia
Aneurysm
Cross-Sectional Studies
Dogs

Keywords

  • Aneurysm, aortic, 89.73
  • Aneurysm, therapy, 89.459, 981.1268
  • Interventional procedures, experimental, 89.459, 981.1268
  • Stents and prostheses, 981.1268

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Palmaz, J. C., Tio, F. O., Laborde, J. C., Clem, M., Rivera, F. J., Murphy, K. D., & Encarnacion, C. E. (1995). Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm. Journal of Vascular and Interventional Radiology, 6(6), 879-885. https://doi.org/10.1016/S1051-0443(95)71207-6

Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm. / Palmaz, Julio C; Tio, Fermin O.; Laborde, Jean Claude; Clem, Michael; Rivera, Frank J.; Murphy, Kenneth D.; Encarnacion, Carlos E.

In: Journal of Vascular and Interventional Radiology, Vol. 6, No. 6, 1995, p. 879-885.

Research output: Contribution to journalArticle

Palmaz, JC, Tio, FO, Laborde, JC, Clem, M, Rivera, FJ, Murphy, KD & Encarnacion, CE 1995, 'Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm', Journal of Vascular and Interventional Radiology, vol. 6, no. 6, pp. 879-885. https://doi.org/10.1016/S1051-0443(95)71207-6
Palmaz, Julio C ; Tio, Fermin O. ; Laborde, Jean Claude ; Clem, Michael ; Rivera, Frank J. ; Murphy, Kenneth D. ; Encarnacion, Carlos E. / Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm. In: Journal of Vascular and Interventional Radiology. 1995 ; Vol. 6, No. 6. pp. 879-885.
@article{17e611d4b3224a4f8c5a278cdaf0508d,
title = "Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm",
abstract = "Purpose: To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE). Materials and Methods: Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples. Results: Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12{\%} and 17{\%} from controls, respectively. Conclusion: Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.",
keywords = "Aneurysm, aortic, 89.73, Aneurysm, therapy, 89.459, 981.1268, Interventional procedures, experimental, 89.459, 981.1268, Stents and prostheses, 981.1268",
author = "Palmaz, {Julio C} and Tio, {Fermin O.} and Laborde, {Jean Claude} and Michael Clem and Rivera, {Frank J.} and Murphy, {Kenneth D.} and Encarnacion, {Carlos E.}",
year = "1995",
doi = "10.1016/S1051-0443(95)71207-6",
language = "English (US)",
volume = "6",
pages = "879--885",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm

AU - Palmaz, Julio C

AU - Tio, Fermin O.

AU - Laborde, Jean Claude

AU - Clem, Michael

AU - Rivera, Frank J.

AU - Murphy, Kenneth D.

AU - Encarnacion, Carlos E.

PY - 1995

Y1 - 1995

N2 - Purpose: To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE). Materials and Methods: Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples. Results: Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12% and 17% from controls, respectively. Conclusion: Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.

AB - Purpose: To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE). Materials and Methods: Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples. Results: Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12% and 17% from controls, respectively. Conclusion: Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.

KW - Aneurysm, aortic, 89.73

KW - Aneurysm, therapy, 89.459, 981.1268

KW - Interventional procedures, experimental, 89.459, 981.1268

KW - Stents and prostheses, 981.1268

UR - http://www.scopus.com/inward/record.url?scp=0029395848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029395848&partnerID=8YFLogxK

U2 - 10.1016/S1051-0443(95)71207-6

DO - 10.1016/S1051-0443(95)71207-6

M3 - Article

C2 - 8850664

AN - SCOPUS:0029395848

VL - 6

SP - 879

EP - 885

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 6

ER -