Use of Stents Covered with Polytetrafluoroethylene in Experimental Abdominal Aortic Aneurysm

Julio C Palmaz, Fermin O. Tio, Jean Claude Laborde, Michael Clem, Frank J. Rivera, Kenneth D. Murphy, Carlos E. Encarnacion

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Purpose: To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE). Materials and Methods: Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples. Results: Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12% and 17% from controls, respectively. Conclusion: Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.

Original languageEnglish (US)
Pages (from-to)879-885
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Issue number6
StatePublished - Nov 1995
Externally publishedYes


  • Aneurysm, aortic, 89.73
  • Aneurysm, therapy, 89.459, 981.1268
  • Interventional procedures, experimental, 89.459, 981.1268
  • Stents and prostheses, 981.1268

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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