Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

L. Almasy; C. Tierney; N. Risch

doi:10.1002/gepi.1370120607

Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

L. Almasy, C. Tierney, N. Risch

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	565-570
Number of pages	6
Journal	Genetic epidemiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/gepi.1370120607
State	Published - 1995

Keywords

TDT
affected sibling‐pairs
association
components of variance
sibling risk ratio
simulation

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

Access to Document

10.1002/gepi.1370120607

Cite this

@article{304df9d915df40858fa59da0de9bb571,

title = "Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease",

abstract = "Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. {\textcopyright}1995 Wiley‐Liss, Inc.",

keywords = "TDT, affected sibling‐pairs, association, components of variance, sibling risk ratio, simulation",

author = "L. Almasy and C. Tierney and N. Risch",

year = "1995",

doi = "10.1002/gepi.1370120607",

language = "English (US)",

volume = "12",

pages = "565--570",

journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "6",

}

TY - JOUR

T1 - Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

AU - Almasy, L.

AU - Tierney, C.

AU - Risch, N.

PY - 1995

Y1 - 1995

N2 - Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley‐Liss, Inc.

AB - Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley‐Liss, Inc.

KW - TDT

KW - affected sibling‐pairs

KW - association

KW - components of variance

KW - sibling risk ratio

KW - simulation

UR - http://www.scopus.com/inward/record.url?scp=0029568046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029568046&partnerID=8YFLogxK

U2 - 10.1002/gepi.1370120607

DO - 10.1002/gepi.1370120607

M3 - Article

C2 - 8787974

AN - SCOPUS:0029568046

VL - 12

SP - 565

EP - 570

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - 6

ER -

Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this