Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

L. Almasy, C. Tierney, N. Risch

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    5 Scopus citations

    Abstract

    Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)565-570
    Number of pages6
    JournalGenetic epidemiology
    Volume12
    Issue number6
    DOIs
    StatePublished - 1995

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    Keywords

    • TDT
    • affected sibling‐pairs
    • association
    • components of variance
    • sibling risk ratio
    • simulation

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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