Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

L. Almasy; C. Tierney; N. Risch

doi:10.1002/gepi.1370120607

Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

L. Almasy, C. Tierney, N. Risch

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	565-570
Number of pages	6
Journal	Genetic epidemiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/gepi.1370120607
State	Published - 1995

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Keywords

TDT
affected sibling‐pairs
association
components of variance
sibling risk ratio
simulation

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

Cite this

Almasy, L., Tierney, C., & Risch, N. (1995). Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease. Genetic epidemiology, 12(6), 565-570. https://doi.org/10.1002/gepi.1370120607

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10.1002/gepi.1370120607