Use of protein A-treated sera in unmasking herpes simplex virus type 1 (HSV-1) immunoglobulin A and identifying HSV-1 immunoglobulin G as the predominant neutralizing antibody

J. J. Ratner, B. A. Sanford, K. O. Smith

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Treatment of human sera with protein A reduced the amounts of immunoglobulin G (IgG), IgA, and IgM detected by radial immunodiffusion. This treatment also decreased the amount of herpes-specific IgG and IgM detected by radioimmunoassay, whereas it increased and even unmasked the amount of herpes-specific IgA detected. Comparison of protein A-treated sera with untreated sera indicated that herpes simplex virus type 1 IgG was responsible for more than 92 to 99% of the serum neutralizing activity.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalJournal of clinical microbiology
Volume10
Issue number4
DOIs
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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