Use of MSCs in antiaging strategies

Travis J. Block, David D Dean, Xiao Dong Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autologous mesenchymal stem cell (MSC)-based therapies are preferable due to biosafety concerns. In addition, increasing evidence suggests that MSCs may not be immune privileged. However, the quantity and quality of MSCs decline with age and limit the effectiveness and regenerative potential of autologous MSC therapies in elderly patients. Interestingly, we have observed that a subpopulation of MSCs (5%-10% of the total population) from elderly donors possess a more “youthful” phenotype. The activity of these “youthful” cells in vivo may be deeply suppressed by the aging environment, and the viability of these cells is diminished by harmful factors released by neighboring senescent cells during expansion in culture. In this chapter, we discuss principles for the use of MSCs in antiaging, and specifically describe a novel strategy for isolating and expanding this “youthful” subpopulation from elderly patients to bank large quantities of high-quality autologous MSCs for treating age-related diseases.

Original languageEnglish (US)
Title of host publicationA Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics
Subtitle of host publicationFrom the Bench to the Clinic
PublisherElsevier
Pages443-461
Number of pages19
ISBN (Electronic)9780128119204
ISBN (Print)9780128119211
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aging
  • Antiaging
  • Rejuvenation of aging MSCs
  • Stem cell banks
  • Stem cell niche

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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