Use of intrathoracic pressure regulation therapy in breathing patients for the treatment of hypotension secondary to trauma

Victor A. Convertino, Brent A. Parquette, David A. Wampler, Craig A. Manifold, David A. Lindstrom, Lori L. Boland, Nathan T. Burkhart, Keith G. Lurie, Charles J. Lick

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Intrathoracic pressure regulation (IPR) therapy has been shown to increase blood pressure in hypotensive patients. The potential value of this therapy in patients with hypotension secondary to trauma with bleeding is not well understood. We hypothesized that IPR would non-invasively and safely enhance blood pressure in spontaneously breathing patients with trauma-induced hypotension. Methods: This prospective observational cohort study assessed vital signs from hypotensive patients with a systolic blood pressure (SBP) ≤90 mmHg secondary to trauma treated with IPR (ResQGARD™, ZOLL Medical) by pre-hospital emergency medical personnel in three large US metropolitan areas. Upon determination of hypotension, facemask-based IPR was initiated as long as bleeding was controlled. Vital signs were recorded before, during, and after IPR. An increased SBP with IPR use was the primary study endpoint. Device tolerance and ease of use were also reported. Results: A total of 54 patients with hypotension secondary to trauma were treated from 2009 to 2016. The mean ± SD SBP increased from 80.9 ± 12.2 mmHg to 106.6 ± 19.2 mmHg with IPR (p < 0.001) and mean arterial pressures (MAP) increased from 62.2 ± 10.5 mmHg to 81.9 ± 16.6 mmHg (p < 0.001). There were no significant changes in mean heart rate or oxygen saturation. Approximately 75% of patients reported moderate to easy tolerance of the device. There were no safety concerns or reported adverse events. Conclusions: These findings support the use of IPR to treat trauma-induced hypotension as long as bleeding has been controlled.

Original languageEnglish (US)
Article number105
JournalScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Issue number1
StatePublished - Oct 30 2017


  • Hemodynamics
  • Hypotension
  • Hypotensive resuscitation
  • Impedance threshold device
  • Trauma

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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