Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia

H. Bittencourt, A. F. Tibúrcio Ribeiro, V. Nobre, L. C. Neuenschwander, A. L. Teixeira, S. G. Xavier, F. D.F. Paula, M. M. Teixeira, J. C.A. Teixeira

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Febrile neutropenia remains a frequent complication in onco-hematological patients, and changes in the circulating level of inflammatory molecules (IM) may precede the occurrence of fever. The present observational prospective study was carried out to evaluate the behavior of plasma tumor necrosis factor alpha (TNF- α), soluble TNF-α I and II receptors (sTNFRI and sTNFRII), monocyte chemoattractant protein- 1 [MCP-1 or chemokine (c-c motif) ligand 2 (CCL2)], macrophage inflammatory protein-1 α (MIP-1 α or CCL3), eotaxin (CCL11), interleukin-8 (IL-8 or CXCL8), and interferon-inducible protein-10 (IP-10 or CXCL10) in 32 episodes of neutropenia in 26 onco-hematological patients. IM were tested on enrollment and 24-48 h before the onset of fever and within 24 h of the first occurrence of fever. Eight of 32 episodes of neutropenia did not present fever (control group) and the patients underwent IM tests on three different occasions. sTNFRI levels, measured a median of 11 h (1-15) before the onset of fever, were significantly higher in patients presenting fever during follow-up compared to controls (P = 0.02). Similar results were observed for sTNFRI and CCL2 levels (P = 0.04 for both) in non-transplanted patients. A cut-off of 1514 pg/mL for sTNFRI was able to discriminate between neutropenic patients with or without fever during follow-up, with 65% sensitivity, 87% specificity, and 93% positive predictive value. Measurement of the levels of plasma sTNFRI can be used to predict the occurrence of fever in neutropenic patients.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalBrazilian Journal of Medical and Biological Research
Issue number2
StatePublished - Jan 2013
Externally publishedYes


  • Cytokines
  • Neutropenia
  • Oncological hematology

ASJC Scopus subject areas

  • Biophysics
  • General Neuroscience
  • Biochemistry
  • Physiology
  • Immunology
  • General Pharmacology, Toxicology and Pharmaceutics
  • Cell Biology


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