Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS

A. J. Berry, M. G. Rinaldi, J. R. Graybill

Research output: Contribution to journalComment/debatepeer-review

79 Scopus citations

Abstract

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

Original languageEnglish (US)
Pages (from-to)690-692
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume36
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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