Use of functional assays to detect and quantify functional selectivity

William P Clarke, Kelly A Berg

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development.

Original languageEnglish (US)
JournalDrug Discovery Today: Technologies
Volume7
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Biotechnology
  • Molecular Medicine

Cite this

Use of functional assays to detect and quantify functional selectivity. / Clarke, William P; Berg, Kelly A.

In: Drug Discovery Today: Technologies, Vol. 7, No. 1, 03.2010.

Research output: Contribution to journalArticle

@article{34d772b2a5b24305ba99781dc1fc92fd,
title = "Use of functional assays to detect and quantify functional selectivity",
abstract = "Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development.",
author = "Clarke, {William P} and Berg, {Kelly A}",
year = "2010",
month = "3",
doi = "10.1016/j.ddtec.2010.07.001",
language = "English (US)",
volume = "7",
journal = "Drug Discovery Today: Technologies",
issn = "1740-6749",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Use of functional assays to detect and quantify functional selectivity

AU - Clarke, William P

AU - Berg, Kelly A

PY - 2010/3

Y1 - 2010/3

N2 - Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development.

AB - Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development.

UR - http://www.scopus.com/inward/record.url?scp=78649903879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649903879&partnerID=8YFLogxK

U2 - 10.1016/j.ddtec.2010.07.001

DO - 10.1016/j.ddtec.2010.07.001

M3 - Article

C2 - 24103682

AN - SCOPUS:78649903879

VL - 7

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

SN - 1740-6749

IS - 1

ER -