Use of functional assays to detect and quantify functional selectivity

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development.

Original languageEnglish (US)
Pages (from-to)e31-e36
JournalDrug Discovery Today: Technologies
Issue number1
StatePublished - 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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