Use of cyclotron produced oxygen-15 to study oxygen carrying capacity of free and liposome encapsulated hemoglobin

William T Phillips, L. Dixon, R. Klipper, A. S. Rudolph, R. Cliff, M. E. Emch, Paul A Jerabek, C. C. Martin, Peter T Fox, B. Goins

Research output: Contribution to journalArticle

Abstract

A new method to study the uptake of oxygen from the lungs is demonstrated. The method uses the short lived positron emitting isotope, oxygen-15. Four formulations were studied in four rats each: liposome encapsulated bovine hemoglobin (LEBH), liposome encapsulated human hemolysate (LEHH), free bovine hemoglobin (HEM), and a control saline solution (SAL). The studies demonstrate the feasibility of using this method to assess the oxygen carrying capacity of various blood substitutes.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994

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Cyclotrons
Liposomes
Hemoglobin
Conservation of Natural Resources
Hemoglobins
Oxygen Isotopes
Oxygen
Blood Substitutes
Positrons
Blood substitutes
Sodium Chloride
Rats
Feasibility Studies
Isotopes
Electrons
Lung

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Use of cyclotron produced oxygen-15 to study oxygen carrying capacity of free and liposome encapsulated hemoglobin. / Phillips, William T; Dixon, L.; Klipper, R.; Rudolph, A. S.; Cliff, R.; Emch, M. E.; Jerabek, Paul A; Martin, C. C.; Fox, Peter T; Goins, B.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

Phillips, WT, Dixon, L, Klipper, R, Rudolph, AS, Cliff, R, Emch, ME, Jerabek, PA, Martin, CC, Fox, PT & Goins, B 1994, 'Use of cyclotron produced oxygen-15 to study oxygen carrying capacity of free and liposome encapsulated hemoglobin', Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, vol. 22, no. 5.
Phillips, William T ; Dixon, L. ; Klipper, R. ; Rudolph, A. S. ; Cliff, R. ; Emch, M. E. ; Jerabek, Paul A ; Martin, C. C. ; Fox, Peter T ; Goins, B. / Use of cyclotron produced oxygen-15 to study oxygen carrying capacity of free and liposome encapsulated hemoglobin. In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 1994 ; Vol. 22, No. 5.
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