Use of cyclotron produced oxygen-15 to study oxygen carrying capacity of free and liposome encapsulated hemoglobin

W. T. Phillips, L. Dixon, R. Klipper, A. S. Rudolph, R. Cliff, M. E. Emch, P. A. Jerabek, C. C. Martin, P. T. Fox, B. Goins

Research output: Contribution to journalConference article

Abstract

A new method to study the uptake of oxygen from the lungs is demonstrated. The method uses the short lived positron emitting isotope, oxygen-15. Four formulations were studied in four rats each: liposome encapsulated bovine hemoglobin (LEBH), liposome encapsulated human hemolysate (LEHH), free bovine hemoglobin (HEM), and a control saline solution (SAL). The studies demonstrate the feasibility of using this method to assess the oxygen carrying capacity of various blood substitutes.

Original languageEnglish (US)
Pages (from-to)A145
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1 1994
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

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ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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