Use of a more physiologic oral glucose solution during testing for gestational diabetes mellitus

J. G. Schwartz, W. T. Phillips, O. Langer

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A lower osmolar oral glucose solution (50 g glucose in 450 mL fluid, 0.62 mol/L) was administered in addition to the standard hyperosmolar oral glucose solution (100 g glucose in 300 mL fluid, 1.85 mol/L) for oral glucose tolerance testing 1 week apart to 102 pregnant women. The standard oral glucose solution creates delayed gastric emptying and is associated with frequent nausea and vomiting. Results using the modified, lower osmolar glucose solution, when compared to the standard hyperosmolar glucose solution showed (1) statistically equivalent glucose excursion values 30 minutes after ingestion, (2) statistically significant decreased plasma glucose values ≥ 60 minutes, (3) no statistically significant difference in insulin excursion values 30 minutes after ingestion, (4) equal area under the curve for glucose at 30 minutes using either solution, and (5) a markedly decreased incidence of nausea and vomiting. These data suggest that the modified, lower osmolar glucose solution empties rapidly from the stomach and allows the glucose to be absorbed and enter the peripheral circulation in an expeditious manner.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number6
DOIs
StatePublished - Jan 1 1992

Keywords

  • Gastric emptying
  • Gestational diabetes mellitus
  • Oral glucose tolerance test
  • Postprandial glucose

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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