Usage of spot urine protein to creatinine ratios in the evaluation of preeclampsia

Thomas L. Wheeler, Dawn W. Blackhurst, Eric H. Dellinger, Patrick S. Ramsey

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective: The objective of the study was to prospectively compare spot urine protein to creatinine (P:C) ratios with 24 hour urine collections for protein in women being evaluated for preeclampsia. Study Design: A spot urine P:C ratio was obtained at the beginning of 24 hour urine collections from 126 patients admitted to evaluate for preeclampsia. Correlation between the spot P:C ratio with the 24 hour urine collections was calculated. Receiver operator characteristic curves were constructed to determine best P:C cut-offs for 300 mg and 5000 mg protein per 24 hours. Results: Random spot P:C ratios were strongly correlated with 24 hour urine protein levels (Pearson r = 0.88). The optimal P:C cut-offs were 0.21 (300 mg per 24 hours) and 3.0 (5000 mg per 24 hours). A P:C ratio of less than 0.21 (300 mg per 24 hours) had a negative predictive value (NPV) of 83.3% and a P:C ratio of less than 3.0 (5000 mg per 24 hours) had 100% NPV. Conclusion: Urine spot P:C ratio correlated well with 24 hour urine collections for protein but was not justified as a substitute for timed collections.

Original languageEnglish (US)
Pages (from-to)465.e1-465.e4
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • creatinine
  • measurement
  • preeclampsia
  • protein

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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