Ursolic acid and chronic disease: An overview of UA’s effects on prevention and treatment of obesity and cancer

Anna M. Mancha-Ramirez, Thomas J Slaga

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

Chronic diseases pose a worldwide problem and are only continuing to increase in incidence. Two major factors contributing to the increased incidence in chronic disease are a lack of physical activity and poor diet. As the link between diet and lifestyle and the increased incidence of chronic disease has been well established in the literature, novel preventive, and therapeutic methods should be aimed at naturally derived compounds such as ursolic acid (UA), the focus of this chapter. As chronic diseases, obesity and cancer share the common thread of inflammation and dysregulation of many related pathways, the focus here will be on these two chronic diseases. Significant evidence in the literature supports an important role for natural compounds such as UA in the prevention and treatment of chronic diseases like obesity and cancer, and here we have highlighted many of the ways UA has been shown to be a beneficial and versatile phytochemical.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages75-96
Number of pages22
Volume928
DOIs
StatePublished - Sep 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume928
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Cancer
  • Inflammation
  • Obesity
  • Phytonutrients
  • Triterpenoids
  • Ursolic acid

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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