Urorectal septum malformation sequence

Daniel H. Williams IV, Philip Fitchev, Maria Luisa C. Policarpio-Nicolas, Eileen Wang, Robert E. Brannigan, Susan E. Crawford

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The urorectal septum malformation sequence consists of absent perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. The full sequence is highly lethal, and the partial sequence, characterized by a single perineal opening draining a common cloaca, is compatible with life. Defects in mesodermal proliferation early in embryogenesis result in this rare condition. Timely urologic and surgical evaluations and reconstructions are imperative and necessary for survival. Urologists should be familiar with the mechanisms and presentations of this condition, as they may be involved in the diagnosis and management of such patients.

Original languageEnglish (US)
Pages (from-to)657.e5-657.e7
Issue number3
StatePublished - Sep 2005
Externally publishedYes

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Urorectal septum malformation sequence'. Together they form a unique fingerprint.

Cite this