Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution

Charles E Brady Iii, Jack A. DiPalma, Stephen G. Morawski, Carol A. Santa Ana, John S. Fordtran

Research output: Contribution to journalArticle

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Abstract

Ingestion of an electrolyte lavage solution containing polyethylene glycol 3350 and sulfate is an effective method of cleansing the colon for diagnostic studies. Polyethylene glycol and sulfate are considered poorly absorbed from the gastrointestinal tract. Because of the quantities administered, concern exists about potential toxicity of absorption of even a small percentage, particularly for polyethylene glycol. We measured the urinary excretion of both -polyethylene glycol and sulfate in normal subjects and inflammatory bowel patients. Absorption of polyethylene glycol can be assessed by measuring recovery in urine, as 85%-96% of an intravenous load is excreted in urine. Similarly, appreciable sulfate absorption would exceed renal tubular reabsorption and result in increased urinary excretion. Mean percent polyethylene glycol load recovered in urine was minimal and similar for normal (0.06%) and inflammatory bowel (0.09%) subjects. Urinary sulfate excretion after lavage was also similar for both groups and was not different from baseline. These results do not suggest the likelihood of toxicity due to polyethylene glycol 3350 or sulfate absorption during gut lavage with this solution.

Original languageEnglish (US)
Pages (from-to)1914-1918
Number of pages5
JournalGastroenterology
Volume90
Issue number6
StatePublished - 1986

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Therapeutic Irrigation
Electrolytes
Sulfates
Urine
Gastrointestinal Tract
polyethylene glycol 3350
Colon
Eating

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Brady Iii, C. E., DiPalma, J. A., Morawski, S. G., Santa Ana, C. A., & Fordtran, J. S. (1986). Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. Gastroenterology, 90(6), 1914-1918.

Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. / Brady Iii, Charles E; DiPalma, Jack A.; Morawski, Stephen G.; Santa Ana, Carol A.; Fordtran, John S.

In: Gastroenterology, Vol. 90, No. 6, 1986, p. 1914-1918.

Research output: Contribution to journalArticle

Brady Iii, CE, DiPalma, JA, Morawski, SG, Santa Ana, CA & Fordtran, JS 1986, 'Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution', Gastroenterology, vol. 90, no. 6, pp. 1914-1918.
Brady Iii, Charles E ; DiPalma, Jack A. ; Morawski, Stephen G. ; Santa Ana, Carol A. ; Fordtran, John S. / Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. In: Gastroenterology. 1986 ; Vol. 90, No. 6. pp. 1914-1918.
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