Uric acid correlates to oxidation and inflammation in opposite directions in women

Sheng Hui Wu, Xiao Ou Shu, Ginger Milne, Yong Bing Xiang, Xianglan Zhang, Qiuyin Cai, Sergio Fazio, MacRae F. Linton, Honglei Chen, Mark Purdue, Nathaniel Rothman, Yu Tang Gao, Wei Zheng, Gong Yang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalBiomarkers
Volume20
Issue number4
DOIs
StatePublished - May 19 2015

Keywords

  • Biomarker
  • inflammation
  • oxidative stress
  • uric acid

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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