Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease

Yves Gorin, Fabien Wauquier

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, the complication of diabetes in the kidney. NADPH oxidases of the Nox family, and in particular the homologue Nox4, are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current knowledge related to the understanding of the role of Nox enzymes in the processes that control mesangial cell, podocyte and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin- angiotensin system and transforming growth factor-p. The nature of the upstream modulators of Nox enzymes as well as the downstream targets of the Nox NADPH oxidases implicated in the propagation of the redox processes that alter renal biology in diabetes will be highlighted.

Original languageEnglish (US)
Pages (from-to)285-296
Number of pages12
JournalMolecules and Cells
Volume38
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Diabetic nephropathy
  • Downstream effectors of Nox NADPH oxidases
  • Nox family of NADPH oxidases
  • Oxidative stress
  • Upstream regulators of Nox NADPH oxidases

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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