TY - JOUR
T1 - Update on Chlamydia trachomatis vaccinology
AU - De La Maza, Luis M.
AU - Zhong, Guangming
AU - Brunham, Robert C.
N1 - Publisher Copyright:
Copyright © 2017 American Society for Microbiology. All Rights Reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/4
Y1 - 2017/4
N2 - Attempts to produce a vaccine to protect against Chlamydia trachomatisinduced trachoma were initiated more than 100 years ago and continued for several decades. Using whole organisms, protective responses were obtained. However, upon exposure to C. trachomatis, disease exacerbation developed in some immunized individuals, precluding the implementation of the vaccine. Evidence of the role of C. trachomatis as a sexually transmitted pathogen started to emerge in the 1960s, and it soon became evident that it can cause acute infections and long-term sequelae in women, men, and newborns. The main focus of this minireview is to summarize recent findings and discuss formulations, including antigens, adjuvants, routes, and delivery systems for immunization, primarily explored in the female mouse model, with the goal of implementing a vaccine against C. trachomatis genital infections.
AB - Attempts to produce a vaccine to protect against Chlamydia trachomatisinduced trachoma were initiated more than 100 years ago and continued for several decades. Using whole organisms, protective responses were obtained. However, upon exposure to C. trachomatis, disease exacerbation developed in some immunized individuals, precluding the implementation of the vaccine. Evidence of the role of C. trachomatis as a sexually transmitted pathogen started to emerge in the 1960s, and it soon became evident that it can cause acute infections and long-term sequelae in women, men, and newborns. The main focus of this minireview is to summarize recent findings and discuss formulations, including antigens, adjuvants, routes, and delivery systems for immunization, primarily explored in the female mouse model, with the goal of implementing a vaccine against C. trachomatis genital infections.
KW - Adjuvants
KW - Antigens
KW - Chlamydia muridarum
KW - Chlamydia trachomatis
KW - Chlamydia trachomatis vaccines
KW - Delivery systems
KW - Routes of immunization
KW - Vaccinology
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U2 - 10.1128/CVI.00543-16
DO - 10.1128/CVI.00543-16
M3 - Review article
C2 - 28228394
AN - SCOPUS:85017554905
VL - 24
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
SN - 1556-6811
IS - 4
M1 - 0054316
ER -