Update on bipolar disorder biomarker candidates

Antonio L. Teixeira, Haitham Salem, Benicio N. Frey, Izabela G. Barbosa, Rodrigo Machado-Vieira

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Introduction: Bipolar disorder is a chronic and disabling mood disorder with a complex pathophysiological basis. A significant percentage of patients do not receive correct diagnosis which directly influences therapeutic response, rendering recovery troublesome. There is a long-standing need for proper non-clinically based tools for diagnosis, treatment selection and follow-up of such patients. Areas covered: In the past decade, the scientific community has shown a great interest in biomarker development. Here, we highlight the different potential biomarkers and we discuss their feasibility and their possible clinical relevance. Expert commentary: To date, despite the major ongoing trials and consortia with promising future perspectives, no reliable biomarker of bipolar disorder has been fully defined.

Original languageEnglish (US)
Pages (from-to)1209-1220
Number of pages12
JournalExpert Review of Molecular Diagnostics
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • biomarkers
  • Bipolar disorder
  • genomic analysis
  • neuroimaging
  • peripheral markers

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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