TY - JOUR
T1 - Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment
AU - Kalluri, Haviryaji S.G.
AU - Mehta, Ashok K.
AU - Ticku, Maharaj K.
N1 - Funding Information:
We thank Ms. Sadie Phillips for excellent secretarial help. This work was supported by funds from National Institute on Alcohol and Alcohol Abuse Grants AA 04090 and AA 10552.
PY - 1998/7/15
Y1 - 1998/7/15
N2 - We investigated the effect of chronic ethanol administration and its withdrawal on the polypeptide levels of NMDA receptor subunits such as NR1, NR2A, and NR2B in the rat cerebral cortex and hippocampus using Western blot analysis technique. Our results indicate that chronic ethanol treatment upregulates NMDA receptor subunits NR1, NR2A, and NR2B (~ 35%). At 48 h of last dose of ethanol administration, the protein content returned to almost control level, thereby demonstrating the reversibility of the changes.
AB - We investigated the effect of chronic ethanol administration and its withdrawal on the polypeptide levels of NMDA receptor subunits such as NR1, NR2A, and NR2B in the rat cerebral cortex and hippocampus using Western blot analysis technique. Our results indicate that chronic ethanol treatment upregulates NMDA receptor subunits NR1, NR2A, and NR2B (~ 35%). At 48 h of last dose of ethanol administration, the protein content returned to almost control level, thereby demonstrating the reversibility of the changes.
KW - Chronic ethanol treatment
KW - NMDA receptor subunit
KW - Up-regulation
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U2 - 10.1016/S0169-328X(98)00112-0
DO - 10.1016/S0169-328X(98)00112-0
M3 - Article
C2 - 9685652
AN - SCOPUS:0032528124
SN - 0006-8993
VL - 58
SP - 221
EP - 224
JO - Brain Research
JF - Brain Research
IS - 1-2
ER -