Unusual lymphoproliferative disorders in nine adults with HIV or AIDS: CT and pathologic findings

Georgeann McGuinness, John V. Scholes, Jaishree S. Jagirdar, Edward Lubat, Barry S. Leitman, Meenakshi Bhalla, Dorothy I. McCauley, Stuart M. Garay, David P. Naidich

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

PURPOSE: To identify characteristic computed tomographic (CT) findings in unusual pulmonary lymphoproliferative disorders seen in adults with the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: The authors retrospectively reviewed the CT scans and pathologic specimens from nine patients with pulmonary lymphoproliferative disorders. CT scans were evaluated for nodules, reticulation, areas of ground-glass attenuation, consolidation, and bronchial disease. Changes seen in pathologic specimens were classified as consistent with classic lymphocytic interstitial pneumonitis (LIP), mucosa-associated lymphoid tissue lymphoma (MALTOMA), or atypical lymphoproliferative disorder (ALD). Immunopathologic results were reviewed when available. RESULTS: Eight patients had AIDS. Five patients had classic LIP. One patient had MALTOMA, and three patients had ALD. Altogether, 2-4-mm-diameter nodules were the predominant CT finding in eight patients; these were peribronchovascular in four patients. The presence of interstitial nodules correlated with the pathologic finding of nodular disease in seven patients. CONCLUSION: Familiarity with these AIDS-related disorders and their CT appearance should assist in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalRadiology
Volume197
Issue number1
DOIs
StatePublished - Oct 1995

Keywords

  • Acquired immunodeficiency syndrome (AIDS)
  • Lymphoma, AIDS- related
  • Lymphoma, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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