Understanding neuropathic corneal pain - Gaps and current therapeutic approaches

Sunali Goyal, Pedram Hamrah

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalSeminars in Ophthalmology
Issue number1-2
StatePublished - Mar 3 2016
Externally publishedYes


  • Autologous serum drops
  • Corneal neural anatomy
  • Corneal pain
  • Dry eye
  • In vivo confocal microscopy
  • Neuropathic pain

ASJC Scopus subject areas

  • Ophthalmology


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