TY - JOUR
T1 - Understanding neuropathic corneal pain - Gaps and current therapeutic approaches
AU - Goyal, Sunali
AU - Hamrah, Pedram
N1 - Funding Information:
This study was supported by NIH R01-EY022695 (PH), Research to Prevent Blindness Career Development Award (PH), and Falk Medical Research Trust (PH). The funding organizations had no role in the design or conduct of this research
Publisher Copyright:
© 2016 Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain.
AB - The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain.
KW - Autologous serum drops
KW - Corneal neural anatomy
KW - Corneal pain
KW - Dry eye
KW - In vivo confocal microscopy
KW - Neuropathic pain
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U2 - 10.3109/08820538.2015.1114853
DO - 10.3109/08820538.2015.1114853
M3 - Review article
C2 - 26959131
AN - SCOPUS:84962179503
VL - 31
SP - 59
EP - 70
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
SN - 0882-0538
IS - 1-2
ER -