Underlying cause of death in incident unprovoked seizures in the urban community of Northern Manhattan, New York City

Emma K.T. Benn, W. Allen Hauser, Tina Shih, Linda Leary, Emilia Bagiella, Peter Dayan, Robert Green, Howard Andrews, David J. Thurman, Dale C. Hesdorffer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We determined underlying cause-specific mortality for incident unprovoked seizures from Northern Manhattan, New York City. We calculated the case fatality, proportionate mortality, and the underlying cause-specific standardized mortality ratios (SMRs), with U.S. death rates as the standard. Thirty-two deaths were observed between 2003 and 2007 among 209 participants. Case fatality was significantly lower for idiopathic/cryptogenic seizures versus symptomatic seizures. About 31.3% of the deaths were attributed to malignant neoplasms, 25.0% to diseases of the heart, 15.6% to influenza and pneumonia, 3.1% to cerebrovascular diseases, and 25.0% to other causes. Significant SMRs were observed for all causes (SMR = 1.6), influenza and pneumonia (SMR = 7.1), and malignant neoplasms (SMR = 2.9). Younger cases (<65 years) had increased SMRs for all causes, malignant neoplasms, and other causes. Older cases (≥65 years) had increased SMRs for influenza and pneumonia. Underlying cause of death paralleled the underlying cause of seizure in patients with symptomatic etiologies.

Original languageEnglish (US)
Pages (from-to)2296-2300
Number of pages5
JournalEpilepsia
Volume50
Issue number10
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Keywords

  • Epidemiology
  • Epilepsy
  • Mortality

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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