Ultrahigh molecular weight polyethylene particles have direct effects on proliferation, differentiation, and local factor production of MG63 osteoblast-like cells

D. D. Dean, Z. Schwartz, C. R. Blanchard, Y. Liu, C. M. Agrawal, C. H. Lohmann, V. L. Sylvia, B. D. Boyan

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Ultrahigh molecular weight polyethylene (UHMWP) particles were characterized and their effect on the wear properties of osteoblast-like cells were investigated. In aliquots of the culture medium containing UHMWP, 79% of the particles were less than 1 μm in diameter, indicating that the cells were exposed to particles less than 1 μm. UHMWP particles influenced the MG63 proliferation, differentiation, extracellular matrix synthesis, local factor production. These effects were direct and dose dependent. UHMWP wear debris particles with an average size of approximately 1 μm may inhibit bone formation by inhibiting cell differentiation and reducing transforming growth factor-β production and matrix synthesis.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalJournal of Orthopaedic Research
Volume17
Issue number1
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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