Type IIB von Willebrand's disease: Unusual responses to cryoprecipitate infusion

R. S. Weinger, P. L. Cimo, J. L. Moake, John D Olson, M. S. Heller

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 16-year-old boy had IIB von Willebrand's disease. The disorder is characterized by prolonged bleeding times; normal plasma levels of factor VIII-coagulant activity, factor VIII-ristocetin cofactor activity, and factor VIII-related antigen; abnormal (anodal) mobility of plasma factor VIII-related antigen on two-dimensional crossed immunoelectrophoresis; and enhanced binding of plasma factor VII-related antigen to normal platelets in the presence of ristocetin. These variables were measured at time periods after an infusion of normal cryoprecipitate into the patient. The electrophoretic mobility of his plasma factor VIII-related antigen was normal 15 minutes after the infusion but became abnormal (anodal) by 4 hours. His bleeding times were normal after 24 hours and did not correlate with plasma levels of factor VIII-coagulant activity, factor VIII-ristocetin cofactor, factor VIII-related antigen, or the electrophoretic mobility of his plasma factor VIII-related antigen. These results imply that the abnormal factor VIII/von Willbrand factor multimers and delay the deposition of the normal multimers into subendothelial surfaces. This may require cryoprecipitate infusions 24 hours before elective surgical procedures.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalAnnals of Internal Medicine
Volume94
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Type 2 von Willebrand Disease
von Willebrand Factor
Factor VIII
Two-Dimensional Immunoelectrophoresis
Coagulants
Bleeding Time
Elective Surgical Procedures
Ristocetin
von Willebrand Diseases
Blood Platelets

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Weinger, R. S., Cimo, P. L., Moake, J. L., Olson, J. D., & Heller, M. S. (1981). Type IIB von Willebrand's disease: Unusual responses to cryoprecipitate infusion. Annals of Internal Medicine, 94(1), 47-50.

Type IIB von Willebrand's disease : Unusual responses to cryoprecipitate infusion. / Weinger, R. S.; Cimo, P. L.; Moake, J. L.; Olson, John D; Heller, M. S.

In: Annals of Internal Medicine, Vol. 94, No. 1, 1981, p. 47-50.

Research output: Contribution to journalArticle

Weinger, RS, Cimo, PL, Moake, JL, Olson, JD & Heller, MS 1981, 'Type IIB von Willebrand's disease: Unusual responses to cryoprecipitate infusion', Annals of Internal Medicine, vol. 94, no. 1, pp. 47-50.
Weinger RS, Cimo PL, Moake JL, Olson JD, Heller MS. Type IIB von Willebrand's disease: Unusual responses to cryoprecipitate infusion. Annals of Internal Medicine. 1981;94(1):47-50.
Weinger, R. S. ; Cimo, P. L. ; Moake, J. L. ; Olson, John D ; Heller, M. S. / Type IIB von Willebrand's disease : Unusual responses to cryoprecipitate infusion. In: Annals of Internal Medicine. 1981 ; Vol. 94, No. 1. pp. 47-50.
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