Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells

Jamie L. Shirley, Geoffrey D. Keeler, Alexandra Sherman, Irene Zolotukhin, David M. Markusic, Brad E. Hoffman, Laurence M. Morel, Mark A. Wallet, Cox Terhorst, Roland W. Herzog

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Immune responses complicate the use of adeno-associated virus (AAV) vectors in human gene therapy. Shirley et al. define a mechanism by which cross-presentation of viral capsid results in activation of CD8+ T cells, which involves sensing of IFN I by conventional dendritic cells and co-stimulation by CD4+ T helper cells.

Original languageEnglish (US)
Pages (from-to)758-770
Number of pages13
JournalMolecular Therapy
Volume28
Issue number3
DOIs
StatePublished - Mar 4 2020
Externally publishedYes

Keywords

  • adeno-associated virus
  • CD8 T cell
  • dendritic cell
  • innate immunity
  • type I interferon

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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