@article{8ae52b8ae04448e7a9055b98d76bb28d,
title = "Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells",
abstract = "Immune responses complicate the use of adeno-associated virus (AAV) vectors in human gene therapy. Shirley et al. define a mechanism by which cross-presentation of viral capsid results in activation of CD8+ T cells, which involves sensing of IFN I by conventional dendritic cells and co-stimulation by CD4+ T helper cells.",
keywords = "adeno-associated virus, CD8 T cell, dendritic cell, innate immunity, type I interferon",
author = "Shirley, {Jamie L.} and Keeler, {Geoffrey D.} and Alexandra Sherman and Irene Zolotukhin and Markusic, {David M.} and Hoffman, {Brad E.} and Morel, {Laurence M.} and Wallet, {Mark A.} and Cox Terhorst and Herzog, {Roland W.}",
note = "Funding Information: This work was supported by NIH National Institute of Allergy and Infectious Diseases Grant R01 AI51390 (to R.W.H), NIH National Heart, Lung, and Blood Institute Grants R01 HL131093 (to R.W.H. and C.T.) and R01 HL097088 (to R.W.H.), and Indiana Collaborative Initiative for Talent Enrichment (INCITE) funds provided by Lilly Endowment. Funding Information: This work was supported by NIH National Institute of Allergy and Infectious Diseases Grant R01 AI51390 (to R.W.H), NIH National Heart, Lung, and Blood Institute Grants R01 HL131093 (to R.W.H. and C.T.) and R01 HL097088 (to R.W.H.), and Indiana Collaborative Initiative for Talent Enrichment (INCITE) funds provided by Lilly Endowment . Publisher Copyright: {\textcopyright} 2019 The American Society of Gene and Cell Therapy",
year = "2020",
month = mar,
day = "4",
doi = "10.1016/j.ymthe.2019.11.011",
language = "English (US)",
volume = "28",
pages = "758--770",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "3",
}