Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

Andreea Ciudin; Ana Espinosa; Olga Simó-Servat; Agustín Ruiz; Montserrat Alegret; Cristina Hernández; Mercè Boada; Rafael Simó

doi:10.1016/j.jdiacomp.2017.04.018

Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

Andreea Ciudin, Ana Espinosa, Olga Simó-Servat, Agustín Ruiz, Montserrat Alegret, Cristina Hernández, Mercè Boada, Rafael Simó

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Aims To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods A longitudinal nested case–control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia. Conclusion T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.

Original language	English (US)
Pages (from-to)	1272-1274
Number of pages	3
Journal	Journal of Diabetes and Its Complications
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.jdiacomp.2017.04.018
State	Published - Aug 2017
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.jdiacomp.2017.04.018

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title = "Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment",

abstract = "Aims To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods A longitudinal nested case–control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia. Conclusion T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.",

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T1 - Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

AU - Ciudin, Andreea

AU - Espinosa, Ana

AU - Simó-Servat, Olga

AU - Ruiz, Agustín

AU - Alegret, Montserrat

AU - Hernández, Cristina

AU - Boada, Mercè

AU - Simó, Rafael

PY - 2017/8

Y1 - 2017/8

N2 - Aims To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). Methods A longitudinal nested case–control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. Results The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p = 0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia. Conclusion T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.

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Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

Abstract

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