TY - JOUR
T1 - Two NF1 translocations map within a 600-kilobase segment of 17q11.2
AU - O'Connell, Peter
AU - Leach, Robin
AU - Cawthon, Richard M.
AU - Culver, Melanie
AU - Stevens, Jeffrey
AU - Viskochil, David
AU - Fournier, R. E.Keith
AU - Rich, Donna C.
AU - Ledbetter, David H.
AU - White, Ray
PY - 1989
Y1 - 1989
N2 - Balanced translocations, each involving chromosome 17q11.2, have been described in two patients with von Recklinghausen neurofibromatosis (NF1). To better localize the end points of these translocation events, and the NF1 gene (NF1) itself, human cosmids were isolated and mapped in the immediate vicinity of NF1. One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment.
AB - Balanced translocations, each involving chromosome 17q11.2, have been described in two patients with von Recklinghausen neurofibromatosis (NF1). To better localize the end points of these translocation events, and the NF1 gene (NF1) itself, human cosmids were isolated and mapped in the immediate vicinity of NF1. One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment.
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U2 - 10.1126/science.2543077
DO - 10.1126/science.2543077
M3 - Article
C2 - 2543077
AN - SCOPUS:0024396040
SN - 0036-8075
VL - 244
SP - 1087
EP - 1088
JO - Science
JF - Science
IS - 4908
ER -