Twins with Two Different Fathers Identified by HLA

Paul I. Terasaki, David Gjertson, Domenico Bernoco, Sondra Perdue, Max R. Mickey, Judy Bond

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


WE recently reported 1000 cases of disputed paternity in which the HLA typing test proved to be substantially more powerful than the previously used red-cell tests.1 The remarkable efficacy of HLA typing in paternity determinations is attributable to the fact that all HLA haplotypes are relatively rare in the population. Thus, if a putative father shares a combination of HLA types with a child, it is highly probable that he is in fact the true father. This circumstance of shared rare blood types arises in very few cases with red-cell tests because of the allele frequency distributions in these systems.

Original languageEnglish (US)
Pages (from-to)590-592
Number of pages3
JournalNew England Journal of Medicine
Issue number11
StatePublished - Sep 14 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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