Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice

B. H. Babu, B. S. Shylesh, J. Padikkala

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Alcoholic extract of Acanthus ilicifolius (250,500 mg/kg b wt) was found to be effective against tumour progression and carcinogen induced skin papilloma formation in mice. The extract was found to be cytotoxic towards lung fibroblast (L-929) cells in 72 h MTT assay and the concentration required for 50% cell death was 18 μg/ml. Oral administration of the extract (500 mg/kg b wt) reduced the tumour volume and administration of the same concentration increased the life span by 75% in ascites tumour (EAC cells) harbouring animals. The extract also significantly delayed the onset of dimethylbenzanthrazene DMBA/Croton oil induced skin papilloma in mice in a dose dependent manner.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalJournal of Ethnopharmacology
Volume79
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Acanthus ilicifolius
  • Antitumour activity
  • Carcinogenesis
  • Cytotoxicity
  • MTT assay

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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