Tumor stem cells and metastasis

Jaclyn Y. Hung

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The last decade has seen the emergence of a shift in paradigm in the therapeutic strategies to target cancer. This is based on the existence of a small reservoir of cells within the tumor mass that exhibits the capacity for self-renewal, as well as undergo differentiation to give rise to phenotypically heterogeneous progeny with limited proliferative potential. These stem-like cells likely drive the continued growth of the tumor mass and are capable of disseminating and are subsequently metastasized. Relapse is probably orchestrated by the post-therapy residual drug-resistant "cancer stem" cells that escape treatment. Therefore, the selective targeting of cancer stem cells is supposed to offer radical advances in the treatment and diagnosis of lung cancer. This chapter will discuss the emerging data supporting the validity of this notion and consider the growing evidence that cancer stem cells may contribute to tumor progression, drug resistance, metastasis, and speculates about how taking these cells into consideration may affect the way we treat lung cancer in the future.

Original languageEnglish (US)
Title of host publicationLung Cancer Metastasis
Subtitle of host publicationNovel Biological Mechanisms and Impact on Clinical Practice
PublisherSpringer New York
Pages47-63
Number of pages17
ISBN (Print)9781441907714
DOIs
StatePublished - Dec 1 2009

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hung, J. Y. (2009). Tumor stem cells and metastasis. In Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice (pp. 47-63). Springer New York. https://doi.org/10.1007/978-1-4419-0772-1_3