Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation

E. O. Gubernatorova, Alexei V Tumanov

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Ulcerative colitis and Crohn’s disease are the major forms of inflammatory bowel disease. Cytokines of the tumor necrosis factor (TNF) family play an important role in the regulation of intestinal inflammation. In this review, we discuss the function of key cytokines of this family–TNF and lymphotoxin (LT)–in mucosal healing, IgA production, and in control of innate lymphoid cells (ILCs), novel regulators of mucosal homeostasis in the gut. TNF plays a central role in the pathogenesis of inflammatory bowel diseases (IBD). LT regulates group 3 of ILCs and IL-22 production and protects the epithelium against damage by chemicals and mucosal bacterial pathogens. In addition, we discuss major mouse models employed to study the mechanism of intestinal inflammation, their advantages and limitations, as well as application of TNF blockers in the therapy for IBD.

Original languageEnglish (US)
Pages (from-to)1309-1325
Number of pages17
JournalBiochemistry (Moscow)
Volume81
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • inflammatory bowel disease
  • intestinal inflammation
  • lymphotoxin
  • mouse models
  • tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry

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